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False-negative Diffusion-Weighted MR Findings in Acute Ischemic Stroke AJNR 21:1434-1440, Oppenheim,C. et al, 2000 See this aricle in Pubmed Article Abstract We found eight cases (5.8%) of false-negative initial DWI studies, of which four were positive on initial fluid-attenuated inversion recovery (FLAIR) imaging. Follow-up FLAIR/DWI showed a hyperintensity matching clinical presentation in all eight patients. The mean size of the lesion was 0.19 +/= 0.16 cm^3. False-negative studies occurred more often in cases of stroke in the posterior (19%) than in the anterior (2%) circulation or when DWI was obtained within 24 hours after symptom onset.Of the six false-negative vertebrobasilar stroke lesions, five were located in the brain stem. In all, 31% of patients with vertebrobasilar ischemic stroke had a false-negative initial DWI study during the first 24 hours. A false-negative DWI study is not uncommon during the first 24 hours of ischemic stroke. Vertebrobasilar stroke should therefore not be ruled out on the basis of early negative DWI, especially when symptoms persist and are suggestive of this diagnosis.

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(click to filter results - removes previous filter) brainstem,infarction of cerebral infarction cerebral ischemia cerebrovascular accident misdiagnosis MRI MRI,abnormal MRI,diffusion weighted MRI,early changes in CVA MRI,false negative transient ischemic attack vertebral-basilar insufficiency

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